Study on dissolution determination method and dissolution rate of Xindakang Sugar-coated Tablets in vitro
- VernacularTitle:心达康片溶出度测定方法研究及体外溶出度考察
- Author:
Wei WANG
;
Tongling LI
;
Qijie PANG
;
Xiaohong XU
;
Li LI
;
Jian SUN
;
- Publication Type:Journal Article
- Keywords:
Flavonoid of hippophae rhamnoides L;
Xindakang sugar coated tablets;
dissolution rate;
UV spectrophotometry
- From:
Chinese Traditional Patent Medicine
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish the method of dissolution determination for evaluating and improving the quality of Xindakang sugar coated Tablets. Xindakang Sugar coated Tablets from three enterprises were investigated. Methods: To adopt 900mL0.5% Tween80 H 2O as dissolvent and rotating basket method at 100r?min -1 , the cumulative dissolution percentage was determined by UV. The dissolution parameters was obtained by Weibull distribution model and dealed with one way ANOVA. Results: The significant differences in dissolution parameters(T d, T 50 ,m)( P
