Three coumarins from seed of Cnidium monnieri and their multidrug resistance reversal effects
- VernacularTitle:蛇床子中3种逆转肿瘤细胞多药耐药活性香豆素(英文)
- Author:
Qinglin ZHANG
;
Jinghua ZHAO
;
Jianjin BI
;
Jurong CAO
;
Jing SONG
;
Zuze WU
;
- Publication Type:Journal Article
- Keywords:
Cnidium monnieri (L ) Cuss;
coumarin;
multidrug resistance (MDR);
KBV 200
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To isolate the active compounds on reversing multidrug resistance (MDR) of tumor cell from the ethanol extract in the seeds of Cnidium monnieri (L ) Cuss Methods The fractionation directed by bioactivity was carried out with silica gel chromatography and RP HPLC Results Three active coumarins were obtained: imperatorin (Ⅰ), edultin (Ⅱ) and 3′ isobutyryloxy O acetyl columbionetin (Ⅲ) Their sturctures were identified by spectroscopic analysis Conclusion These three compounds have a medium reversing MDR of KBV200 in vitro
