Studies on cetyl-chitosan nanosphere as carriers for paclitaxel
- VernacularTitle:十六烷基壳聚糖纳米微球负载紫杉醇的研究
- Author:
Zhao DAI
;
Duoxian SUN
;
Yao GUO
;
- Publication Type:Journal Article
- Keywords:
paclitaxel;
cetyl chitosan (CTCS);
chitosan (CS);
nanosphere;
drug delivery system
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To prepare and study a suitable carrier for paclitaxel in water. Methods Cetyl chitosan (CTCS), prepared by reacting chitosan (CS) with chlorocetane under alkaline condition, was soluble and spontaneously formed nanosphere about 100 nm in diameter. And the release in vitro from paclitaxel loaded CTCS nanosphere was measured in phosphate buffer solution (PBS, pH=7 4). Results The balanced release concentration of paclitaxel was deceased and half release time (t 1/2 ) was delayed with the increase of substitution degree of alkyl. Conclusion This kind of nanosphere is an excellent carrier for paclitaxel in water.
