Application of uniform-design method used to select best proportion of ingredients in Danxintong
- VernacularTitle:均匀设计在丹心痛最佳配比筛选中的应用
- Author:
Peng GAO
;
Ningfei AN
;
Minghong ZHAO
;
Yulan LIU
;
- Publication Type:Journal Article
- Keywords:
Danxintong (DXT);
uniform design method;
myocardial ischemia
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To define the optimal proportion of four ingredients in Danxintong (DXT). Methods Uniform design method combined with pharmacodynamics (Rat acute myocardial ischemia model was used in this study) was used. Results The optimal proportion and components of DXT (Composed of Rhizoma Chuanxiong, Rhizoma Cyperi, Borneolum Syntheticum, and paeonol) were 5∶ 1.7∶ 1.4∶ 4.4; DXT 138 mg/kg could obviously inhibit acute myocardial ischemia of rats induced by iso prenaline (Iso) and pituiturin (Pit). DXT has antimyocardial ischemia effects in preliminary experimental studies. Conclusion Uniform design method is an effective method to define the optimal proportion of ingredients in DXT;
