EFFECTS OF H-89 AND wortmannin ON THE PROMOTING EFFECTS OF forskolin AND IBMX ON THE REGENERATION OF INJURED RETINAL GANGLION CELLS
- VernacularTitle:H-89和wortmannin对forskolin和IBMX促进受损视网膜节细胞再生作用的影响
- Author:
Yuxiang LIANG
;
Haibiao LI
;
- Publication Type:Journal Article
- Keywords:
Regeneration;
H 89;
wortmannin;
forskolin;
IBMX;
Retinal ganglion cells;
Goldem hamster
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The present study was aimed at investigating the regeneration promoting mechanism of forskolin and IBMX on injured retinal ganglion cells(RGCs). Methods Fluorescent retrograde labeling and autologus sciatic nerve transplanting techniques were used to observe the effects of H 89 or/and wortmannin on the regeneration promoting effects of forskolin and IBMX on injured retinal ganglion cells by intravitreal injection. Results Both H 89 and wortmannin could partly block the promoting effects of forskolin and IBMX on regeneration of injured RGCs, the effects of wortmannin might be more powerful, if united, they could inhibit the effects of forskolin and IBMX completely.Conclusion The regeneration promoting effects of forskolin and IBMX on injured RGCs might be realized by PKA CREB and PI3 K Akt accesses.
