Effects of Tetramethylpyrazine on capillary vasomotion and NO of mesentry in rabbit
- VernacularTitle:川芎嗪对家兔肠系膜微血管运动的作用机理与一氧化氮的关系
- Author:
Keping DI
;
Ligong CHANG
;
Junying DU
;
Kaifeng TIAN
;
- Publication Type:Journal Article
- Keywords:
Tetramethylpyrazine;
mesentery;
capillary vasomotion;
N G monomethyl L arginine;
NO
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The aim of this study was to observe the role of NO in the action of tetramethylpyrazine (TMP) on arterioles vasomotion induced by noradrenaline (NA), in order to make further understand of vasodilation mechanism of TMP.Methods: Albino rabbits weighting 2.0 ～ 2.5 kg were anesthetized. They were ventilated with room air via tracheotomy tube. The arterial pressure was monitored with a pressure transducer attached to a polyethylene canula in the right common carotid artery by four channel polygraph, the intestinal loop was mounted on the stage of an inverted microscope and bathed in balanced Kreb Ringer solution maintained at 37.5 ?C . The inside diameter of arterioles were measured manully on a TV monitor using a TV camera mounted on the microscope. Observe the changes of BP、 microcirculation and filtration of true capillary after injection of TMP 8mg/kg、 N G monomethyl L arginine( L NMMA) 10mg via a cannula in the left carotid artery after topical application of NA(0.8?g) conducted in the measured field. Results:TMP can inhibit spontaneous vasomotion in vasodilation; L NMMA can inhibit it in vasoconstriction stage. L NMMA have no effect on the action of TMP. Conclusions: Endogenous NO has no role in TMP's vasodilation.
