The effects of pantoprazole on patients with upper gastrointestinal bleeding
- VernacularTitle:泮托拉唑钠粉针剂治疗上消化道出血疗效观察
- Author:
Guoming XU
;
- Publication Type:Journal Article
- Keywords:
Pantoprazole;
Upper gastrointestinal bleeding;
Drug therapy
- From:
Chinese Journal of Digestion
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of pantoprazole on patients with upper gastrointestinal bleeding and its safety, as compared with omeprazole. Methods Ninety patients with non variceal upper gastrointestinal bleeding were randomly assigned to two groups. Sixty patients were in the group of pantoprazole, including 24 patients with gastric ulcer, 33 duodenal ulcer and 3 erosive gastritis; 30 patients were in the group of omeprazole, including 9 patients with gastric ulcer, 15 duodenal ulcer and 5 erosive gastritis.Treatment schemes:either pantoprazole or omeprazole 80 mg were added into 250 ml 5% glucose respectively and then infused intravenously. The clinical signs of the patients including the amout of bleeding were observed. Results After the treatment, the symptoms and sings improved significantly in both groups( P 0.05). Both the total effective rate of pantoprazole and omeprazole on upper gastrointestinal bleeding was 96.7%. The rates of side effects were 1.7% in pantoprazole group and 3.4% in omeprazole group. Conclusion Pantoprazole is also an effective and safe drug for the non variceal upper gastrointestinal bleeding.
