Studies on structure, physicochemical properties and anticancer activity of glycyrrhizic acid aniline-platinum complex compounds
- VernacularTitle:甘草酸苯胺铂配合物的结构和理化特性及其抗肿瘤细胞活性的研究
- Author:
Jing ZHANG
;
Runguang SUN
;
Hao QI
;
- Publication Type:Journal Article
- Keywords:
glycyrrhizic acid aniline platinum complex compounds;
anticancer activity;
intensity of magnetic field
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To investigate the structure, physicochemical properties and anticancer activity of three kind of glycyrrhizic acid aniline platinum complex compounds. Methods Using the FT IR methods, elementary analysis and X ray diffraction, the physicochemical properties of the tested drugs were determined; by means of MTT test the inhibitory effects of the drugs on human tumor cell growth were examined, with hematopoietic cell K 562 , melanoma cell LiBr and liver cancer cell 7721 as the model of anticancer activity. Results Experimental values of elemental analysis of three complex compounds tally with the theoretically calculative values. The infrared spectroscopy showed that the functional group location agreed with the structure. The X ray diffraction exhibited that this type of the compounds was monoclinic system. Conclusion The experimental results show that the anticancer activity of the test complex compounds is related to their concentration and ligands. Magnetic field treatment has significant influence on anticancer activity of this type of compounds.
