Effects of scorpion venom active peptides on platelet aggregation, thrombosis in carotid artery and plasma 6-keto-PGF_(1?) and TXB_2 in rabbits and rats
- VernacularTitle:蝎毒活性多肽对兔和大鼠的血小板聚集、大鼠血浆中TXB_2,PGF_(1?)及血栓形成的影响
- Author:
Yimin SONG
;
Benbo GAO
;
Er GAO
;
Lin BAI
;
Xinran LU
;
- Publication Type:Journal Article
- Keywords:
scopion venom active peptides;
platelet aggregation;
carotid thrombosis;
rabbit;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the mechanism of scorpion venom active peptides(SVAPs) on platelet aggregation. Methods: Platelet aggregation in vivo and vitro was determined by turbidimetry. Carotid thrombosis model was induced by electrostimulation. The determination of 6 keto PGF 1 and TXB 2 were performed by radioimmunoassay. Results: SVAPs 0.125,0.25,0.5mg?ml -1 significantly inhibited the rabbit platelet aggregation triggered by thrombase 0.03u.ml -1 , ADP 10u.ml -1 in vitro( P
