Effect of Zhengjian Granule on blood pressure and insulin resistance in spontaneously hypertensive rates
- VernacularTitle:针箭颗粒对自发性高血压大鼠血压及胰岛素抵抗的影响
- Author:
Xiaohu CHEN
;
Weiming JIANG
;
Shuhua TANG
;
- Publication Type:Journal Article
- Keywords:
hypertension;
insulin resistance;
spontaneously hypertensive rats;
Zhengjian Granule
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Effect of Zhengjian Granule(ZJ)(Radix Berberidis, Ramulus Euonymi, Radix Scorphulariae Rhizoma Alismatis) on blood pressure(BP) and insulin resistance(IR) in spontaneously hypertensive rats(SHR) was observed. Methods: Twenty four SHR aged 13 weeks were divided into three groups treated with large and small dosage of ZJ and nothing as compared with age matched six Wister Kyoto rats(WKY). BP, glucose(G) and insulin(I) of fasting, G/I and blood lipid were measured before and after treated 8 weeks and compared among groups. Results: While G of fasting had no difference in respective SHR groups compared with WKY, insulin of fasting was markedly higher and G/I were notably lower than WKY( P
