The clinical and experimental study of thalidomide in the treatment of ankylosing spondylitis
- VernacularTitle:反应停治疗强直性脊柱炎的临床与实验研究
- Author:
Feng HUANG
;
Jieruo GU
;
Wei ZHAO
;
Jian ZHU
;
Jianglin ZHANG
;
De′En YU
;
- Publication Type:Journal Article
- Keywords:
Spondylitis,ankylosing;
Thalidomide;
Oligonucleotide array sequence analysis
- From:
Chinese Journal of Rheumatology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
20% improvement in 4/7 primary indices.Sharp declines in several parameters were noticed during 3 to 6 months.Pain in 9 patients disappeared.There was also a statistically significant decrease in TNF ? transcripts in the PBMC.Conclusion Thalidomide is a reasonably promising drug for treating resistant ankylosing spondylitis and its biological mechanism is related to the gene expression suppression of proinflammatory cytokine TNF ?.
