The Effects of a Single Bolus of Remifentanil on Corrected QT Interval Change during Sevoflurane Induction.
10.3349/ymj.2011.52.2.333
- Author:
Eun Sung KIM
1
;
Hae Wone CHANG
Author Information
1. Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea. haewon7@catholic.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't ; Randomized Controlled Trial
- Keywords:
Laryngeal mask airway;
QTc;
remifentanil;
sevoflurane
- MeSH:
Adult;
Anesthetics, Inhalation/adverse effects/*pharmacology;
Anesthetics, Intravenous/administration & dosage/*pharmacology;
Electrocardiography/drug effects;
Female;
Gynecologic Surgical Procedures/adverse effects;
Heart Rate/*drug effects;
Humans;
Methyl Ethers/adverse effects/*pharmacology;
Middle Aged;
Piperidines/*pharmacology
- From:Yonsei Medical Journal
2011;52(2):333-338
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Opioids may affect changes in the corrected QT interval (QTc) during anesthetic induction. This study examine whether a single bolus of remifentanil would prolong QTc after laryngeal mask airway (LMA) insertion during sevoflurane induction. MATERIALS AND METHODS: Forty women of American Society of Anesthesiologists physical status 1 (ASA PS1) undergoing gynecological surgery were studied. All patients were induced using three vital capacity inhalation inductions with 5% sevoflurane. Two minutes after induction, the inspiratory concentration of sevoflurane was reduced to 2%. Using double-blinded randomization, patients were allocated into one of two groups, receiving either saline (placebo group, n = 20) or 0.25 microg.kg-1 remifentanil (remifentanil group, n = 20) over a period of thirty seconds. Sixty seconds later, LMA insertion was performed. Recordings were taken with a 12-lead electrocardiogram at baseline, 2 min after induction and 1 and 3 min after LMA insertion. QTc was calculated by Bazett's formula. The mean arterial pressure (MAP) and heart rate (HR) were also measured at each time point. RESULTS: The QTc interval was significantly prolonged in the placebo group as compared to the remifentanil group at 1 min after LMA insertion (467.8 +/- 16.5 vs. 442.7 +/- 21.3 ms, p < 0.001). However, there was no significant difference in QTc at 3 min after LMA insertion between the two groups. MAP and HR were significantly higher in the placebo group (p < 0.001). CONCLUSION: A single bolus of remifentanil is safe method to attenuate prolonged QTc associated with insertion of LMA.
