Pharmacological study of Zhiyu prescription on diabetic peripheral neuritis
- VernacularTitle:蛭萸方对糖尿病性周围神经炎的药效学研究
- Author:
Xiaochen ZHANG
;
Jindi JIN
;
Ailiang GU
;
Ping MAO
;
Wenjuan WANG
;
- Publication Type:Journal Article
- Keywords:
Zhiyu prescription;
diabetic peripheral neuritis;
alloxan;
streptozotocin;
nerve conduction
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Zhiyu presciption is composed of Whitmania pigra (Whitman) and Cornus officinalis Sieb. et Zucc. etc. It treats mainly for diabetic peripheral neuritis. To study the pharmacologic effects of Zhiyu prescription in this paper. Methods:The analgesic effect of Zhiyu presciption was examined through writhe method in mice, and the functions of Zhiyu prescription on extrinsic thrombosia and platelet aggregation in normal rats were observed. The model of alloxan induced diabetes in mice was established, the effect of Zhiyu prescription on blood glucose level was detected. The functions of nervus electrophysiology were examined on the model rats of diabetic peripheral neuritis induced by streptozotocin. Results: Zhiyu prescription could decrease the numbers of writhes of mice caused by acetic acid, reduce the blood glucose level in alloxan induced diabetic mice, improve the nervus conduction velocity of motor nerve.Conclusion: Zhiyu prescription is effective in clinical treatment of diabetic peripheral neuritis.
