Effects of octreotide on the proliferation and apoptosis of hepatocellular carcinoma cells
- VernacularTitle:奥曲肽对人肝癌细胞生长增殖、甲胎蛋白合成及细胞凋亡的作用
- Author:
Li HUO
;
Hailin LIU
;
Lei WANG
;
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Octreotide;
Apoptosis;
Proliferation
- From:
Chinese Journal of Digestion
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of octreotide on the proliferation and apoptosis of hepatocellular carcinoma cells, and provide an experimental basis for clinical application. Methods The proliferation of hepatocellular carcinoma cells (HepG2) was assessed by MTT and growth curve respectively, the contents of AFP in the culture supernatant were determined by eletrochemiluminescence immunoassay, and apoptosis was detected by fluorescent staining, transmission electron microscopy and flow cytometry. Results The proliferation of HepG2 was inhibited significantly by octreotide with a dosage dependant manner(range from 0.005 to 80 ?g/ml, P
