The stimulate angiogenesis effect of Shexiangbaosin Pills on the hearts of myocardial infarction rats
- VernacularTitle:麝香保心丸对实验性心肌梗塞大鼠心脏的促血管生成作用
- Author:
Shanshan WANG
;
Yong LI
;
Weihu FAN
;
Ruihong DAI
;
- Publication Type:Journal Article
- Keywords:
Shexiang Baoxin Pills;
angiogenesis;
coronary collateral development;
myocardial infarction
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The stimulate angiogenes effect and mechanism of Shexiangbaoxin Pills on coronary collateral development in the hearts of experimental myocardial infarction rats were studied. Methods:24 myocardial infarction rats were randomly divided into 3 groups, 8 rats in group A were treated with Shexiangbaoxin Pills, 8 rats in group B were treated with Beifuji and heparin, and 8 rats in group C were treated with 0.9% normal saline as control. Infarct area, the contents of VEGF、bFGF and VⅢ factor, and vascular density in the edge of infarct section were measured after 6 weeks treating.Results: Infarct area in group A was obviously less than that in group C, the contents of VEGF、bFGF and VⅢ factor in the edge of infarct section and vascular density in group were significantly increased compared with those in group C. Conclusions: Shexiangbaoxin Pills could stimulate angiogenesis of the collateral branch of coronary artery in ischemic myocardium of rats and showed good protective on myocardial ischemia.
