Effect of Yizhiping Capsules on hemorrheology of experimental rats with hyperlipoidemia and its toxicity on rats
- VernacularTitle:益脂平胶囊对实验性高脂血症大鼠血液流变学影响及对大鼠毒性研究
- Author:
Ruiquan FAN
;
Shaomei YE
;
Baomin AI
;
Tiejiang CHEN
;
Qinying QIU
;
Qing WEI
;
- Publication Type:Journal Article
- Keywords:
Yizhiping Capsules;
hyperlipoidemia;
hemorrheology;
toxicity
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the influence of Yizhiping Capsules on hemorrheology of experimental rats with hyperlipoidemia and its embryonic toxicity, teratogenicity. Methods:① The rat experimental hyperlipoidemia models were established by feeding with high lipid diet for 10 days. Meanwhile Yizhiping was taken orally at dosages of 75、150mg?kg -1 , some indices of hemorrheology markers were observed. ②According to the procedure of toxicology, the rat in the experimental groups were administered with Yizhiping capsules by gavage at a dose of 250、500、1000mg?kg -1 respectively, the embryonic toxicity and teratogenicity were observed. Results:① Yizhiping Capsules could significantly raise electrophoresis mobility of red cell of experimental hyperlipoidemia model rats, and lower the rate of red cell deposit and the viscosity of whole blood as well as plasma ( P
