Study on stability in vitro of Andrographolide
- VernacularTitle:穿心莲内酯体外稳定性研究
- Author:
Botao YU
;
Zhirong ZHANG
;
Wensheng LIU
;
Ting YANG
;
Ping WANG
;
- Publication Type:Journal Article
- Keywords:
andrograholide;
stability;
RP HPLC;
classical isothermal method
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: In order to provide an effective reference to the study on its preparation, the stability in vitro of andrographolide was investigated. Methods: Andrographolide was dissolved in phosphate buffer solutions of different pH values; classical isothermal method was employed; the content of andrographolide was determined by RP HPLC; then the stability of the drug in different biological media and organic solvents at 37?C was investigated. Results: The stability of andrographolide was different at different pH values and was best in the condition of pH=3～5. In biological media, it was most stable in bovine serum and the next was in mice homogenate. Conclusion: In different conditions, the stability of andrographolide was different. It provided a reference to the study on andrographolide and its preparation.
