Effects of Tanshinone on calcium overloading injury in cultured primary cortex neurone
- VernacularTitle:丹参酮对大鼠皮层神经细胞钙超载损伤的保护作用
- Author:
Subing HE
;
Lina HE
;
Jun YANG
;
- Publication Type:Journal Article
- Keywords:
Tanshinone, cortex neuron, calcium overload, caffeine, KCI, NMDA
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects and mechanism of transhinone on calcium overloaded injuried models.Methods: Three injured models induced by caffeine, KCI, and NMDA, respectively, were used to assay the action of tanshinone in cultured primary cortex neurone of baby rats. Results: It was found that tanshinone possessed obvious protective effects on primary neurone in injured models by the way of morphological examination. Crystal violet staining and lactic dehydrogenase (LDH) measurement in supernate also indicated that tanshinone increased number of live neurone and reduced the extent of cell injury significantly.Conclusion: Tanshinone protected rat cortex cells from three kinds of calcium overloadied injured effectively in vitro.
