Studies on correlativity between in vivo and in vitro release of XIANGHE SUPPOSITORY
- VernacularTitle:香荷药条体内外释药相关性的研究
- Author:
Liu YANG
;
Yuanhui DENG
;
Yuzhen DONG
;
- Publication Type:Journal Article
- Keywords:
XIANGHE SUPPOSITORY(XS);
correlativity of in vivo and in vitro XS release;
berberine;
HPLC method
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the correlativity between the in vivo release of healthy volunteers and the in vitro dissolution of XIANGHE SUPPOSITORY(XS). Methods The electromagnetic stirring method was used to determine the in vitro dissolution of XS, and the in vivo release was got by the indirect method, assaying the content of the left XS after it had released in administering system, HPLC was used for the determination of XS with the index of variant content of berberine hydrochloride. Results A good correlativity was shown between the percentage of in vivo release and in vitro dissolution of XS. Conclusion In vitro dissolution test under the given conditions could indicate the in vivo absorption of XS.
