Effect of total flavones isolated from Metasequoia glyptostroboides on platelet aggregation and hemorrheological properties in rats and research of its mechanism
- VernacularTitle:水杉总黄酮对大鼠血小板聚集、血液流变性的作用及机制探讨
- Author:
Ying AO
;
Weiwan LIU
;
Changkai YAN
;
Mingjian SHI
;
Hongying WANG
;
- Publication Type:Journal Article
- Keywords:
total flavones of Metasequoia glyptostroboides Hu et Cheng (FMG);
platelet aggregation;
5 HT release reaction;
NO;
hemorrheological properties
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To observe the effect of total flavones isolated from Metasequoia glyptostroboides Hu et Cheng (FMG) on platelet aggregation, 5 HT of release, content of NO in plasma and hemorrheological parameters in rats. Methods Platelet aggregation was quantified by turbidimetry, release of 5 HT was assayed by fluorescence technique, and content of NO in plasma was determined by spectrophotometry. Results Inhibition of platelet aggregation and release of 5 HT, increase of NO content in plasma, as well as decrease of whole blood viscosity, plasma viscosity, red cell electrophoresis time, red cell specific volume, red cell count and K value in ESR equation were observed in the acute blood stasis rat, thereby the rat's hemorrheological properties were improved. Conclusion FMG is able to inhibit the platelet aggregation and improve the hemorrheological parameters in acute blood stasis rat. The inhibition of release of 5 HT, increase of NO content in plasma and antagonistic action of Ca 2+ may be the mechanism of its actions.
