Protective effect of gypenosides on cerebral cortex and hippocampus in vascular dementia rat
- VernacularTitle:绞股蓝总皂苷对血管性痴呆大鼠大脑皮层及海马的影响
- Author:
Li ZHANG
;
Guangliang WU
;
Xiaoyi CHEN
;
Gang QI
;
- Publication Type:Journal Article
- Keywords:
gypenosides (GP);
dementia;
vascular;
cerebral cortex;
hippocampus
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To observe the effect of gypenosides (GP) on the DNA and RNA in cerebral cortex and hippocampus in vascular dementia rat. Methods Modified Pulsinelli 4 vessel occlusion (4 VO) method was used to establish the models of vascular dementia rat. The acridine orange (AO) method was applied to study the protective effect of GP on the DNA and RNA of cerebral cortex and hippocampus in vascular dementia rat. Results The fluorescent intensity from the DNA and RNA in cerebral cortex and hippocampus of vascular dementia rat is abated as compared with the normal control group. The fluorescent intensity from DNA and RNA of the treatment group administrated GP (200 mg/kg, ig) significantly intensified, as compared with that of non treatment group, and is similar to that of normal group. Conclusion The injury to the DNA and RNA in cerebral cortex and hippocampus in vascular dementia rat was obviously decreased by GP.
