Effect of Dangguishaoyao Powder on three models of memory dysfunction
- VernacularTitle:当归芍药散对多种记忆损伤动物模型的影响
- Author:
Junping KOU
;
Weifeng JIN
;
Min HUA
;
Yongqing YAN
;
- Publication Type:Journal Article
- Keywords:
Dangguishaoyao Powder(DSP);
scopalamine;
AchE;
reserpine;
ovariectomy;
memory dysfunction
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of DSP on three models of memory dysfunction,so as to provide evidence for its potential therapeuticaction for senile dementia.Methods: Three kinds of memory dysfunction are induced by scopolamine,reserpine and ovariectomy respectively,and memory ability is measured through step through and water maze tests.Meanwhile AchE activity in front cortex, hippocampus,striatum and limlic lobe of rats injected scopalamine is determined.Results: DSP can significantly prolong the step through latency,and decrease AchE activity in different parts of rats injeted scopalamine.And DSP can remarkably prolong latency,and increase uterus index of mice after ovariectomy.On the other hand,DSP can shorten water maze latency,enhance the correction percentage of mice injected reserpine.Conclusions:DSP can improve the memory dysfunction possibly through below pathways:(1)enhance the cholinergic system;(2)antagonize the decrease of monoamino transmitter;(3)has the possible estrogen like action.
