Influence of tetrandrine on activity of cholinesterase inhibited by organophosphate
- VernacularTitle:粉防己碱对有机磷酸酯抑制的胆碱酯酶活性的影响
- Author:
Yuqing XIONG
;
Jun FU
;
Hanqing LIU
;
Yanyan LI
;
- Publication Type:Journal Article
- Keywords:
tetrandrine (Tet);
dipterex;
cholinesterase;
reactivator
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To observe the effect of tetrandrine (Tet) on the activity of cholinesterase (ChE) inhibited by organophosphate. Methods Activity of ChE in human blood was determined with Ellman's method and used as an index. Results The cumulative dose effect curves for inhibitory effect of dipterex on ChE were shifted to right and the maximal inhibitory effect of dipterex was obviously declined by Tet. The maximal reactivating rates of inhibited ChE were 20.5%, 38.3% and 80.2% when the concentrations of Tet were 0.4, 0.8 and 1.6 ?g/mL (P
