The Feasibility of Platelet-Rich Fibrin Matrix Filler in a Nude Mouse Model.
10.14730/aaps.2017.23.3.135
- Author:
Hyeon Jun JEON
1
;
Dong Kyu KIM
;
Jeong Woo LEE
;
Kang Young CHOI
;
Ho Yun CHUNG
;
Byung Chae CHO
;
Jun Ho SHIN
;
Seung Ryul LEE
;
Jung Dug YANG
Author Information
1. Department of Plastic and Reconstructive Surgery, Kyungpook National University School of Medicine, Daegu, Korea. lambyang@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Cosmetic techniques;
Fibrin;
Hyaluronic acid;
Hypersensitivity;
Platelet-rich plasma
- MeSH:
Animal Experimentation;
Animals;
Cosmetic Techniques;
Erythema;
Fibrin Tissue Adhesive;
Fibrin*;
Foreign Bodies;
Hyaluronic Acid;
Hypersensitivity;
Magnetic Resonance Imaging;
Methods;
Mice;
Mice, Nude*;
Platelet-Rich Plasma
- From:Archives of Aesthetic Plastic Surgery
2017;23(3):135-142
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: In contrast to fillers made from artificial substances, platelet-rich fibrin matrix (PRFM) filler does not cause hypersensitivity reactions or foreign body reactions. PRFM is also highly accessible in terms of cost. Hence, in this study, the efficacy of PRFM for soft tissue augmentation and volume maintenance was evaluated in an animal experiment. METHODS: Twenty nude mice were injected with hyaluronic acid filler, fibrin glue, PRFM filler, and normal saline (control). The remaining volume was measured 4 times over the course of 8 weeks using the volumetric taping bowl method and magnetic resonance imaging. RESULTS: All nude mice survived and showed no signs of infection, such as erythema or edematous changes, during the study period. Migration of the injected substance was not detected at 2, 4, or 8 weeks after the procedure. The remaining volumes of normal saline at 2, 4, and 8 weeks were 10.50%, 2.00%, and 0.00%; fibrin glue, 20.50%, 9.00%, and 2.50%; hyaluronic acid filler, 82.00%, 35.00%, and 17.33%; and PRFM filler, 70.31%, 26.75%, and 14.37%, respectively. CONCLUSIONS: PRFM filler had a high soft-tissue filling capacity compared with the control. It also showed a similar effect to hyaluronic acid filler. Thus, PRFM filler could be a good alternative for correcting soft-tissue deficits.
