Study on Transdermal Permeability of Psoralen and Isopsoralen
- VernacularTitle:补骨脂素和异补骨脂素体外透皮特性研究
- Author:
Ning ZHANG
;
Lianying XU
;
- Publication Type:Journal Article
- Keywords:
Psoralen;
Isopsoralen;
transdermal permeability;
penetration enhancer
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the transdermal permeability of Psoralen (Pro) and Isopsoralen (Isopro). Methods:V C two compartment was adopted to research the permeability deferences between Pso and Isopso in nude mouse skin in vitro, and investigated the effect of penetration enhancers, such as EtOH, azone and glycerol on the permeability of them. Results: Pso and Isopso are suitable compounds for transdermal delivery system and the permeability coeffient of Isopso is larger than that of Pso. 10% EtOH-1% Azone greatly increased the permeability coefficient. Conclusion: The results can offer reference for Psoralea corylifolia TDS.
