Metachronous Double Primary Cancer after Diagnosis of Gastric Cancer.
- Author:
Jin Young KIM
1
;
Won Young JANG
;
Mi Hwa HEO
;
Kang Kuk LEE
;
Young Rok DO
;
Keon Uk PARK
;
Hong Suk SONG
;
Yoon Nyun KIM
Author Information
1. Division of Hematology/Oncology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea. shs7436@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Stomach neoplasm;
Second primary neoplasms;
Diagnosis
- MeSH:
Breast Neoplasms;
Carcinoma, Hepatocellular;
Cause of Death;
Colorectal Neoplasms;
Esophageal Neoplasms;
Female;
Follow-Up Studies;
Humans;
Laryngeal Neoplasms;
Lung Neoplasms;
Male;
Neoplasms, Second Primary;
Ovarian Neoplasms;
Prostatic Neoplasms;
Stomach Neoplasms;
Uterine Cervical Neoplasms
- From:Cancer Research and Treatment
2012;44(3):173-178
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The pattern of double primary cancers after treatment for gastric cancer is important for a patient's survival. MATERIALS AND METHODS: We analyzed the clinicopathologic data of 214 gastric cancer patients from October 1996 to November 2007 with regard to metachronous second primary cancers. RESULTS: Out of 5,778 patients with gastric cancer, metachronous second primary cancers occurred in 214 patients. The median age was 61.8 years, the number of male and female patients was 140 (65.4%), 74 (34.6%), respectively. The median time to the occurrence of second cancers after diagnosis of the first was 39.2 months (standard deviation, 31.2 months). The most common cancer was colorectal cancer, which occurred in 44 patients (20.6%), and lung cancer in 33 patients (15.4%), hepatocellular carcinoma in 26 patients (12.1%), ovarian cancer in 15 patients (7.0%), cervical cancer in 12 patients (7.0%), breast cancer in 11 patients (5.1%), and esophageal cancer in 11 patients (5.1%). The observed/expected (O/E) ratio showed a significant increase in colorectal (1.25), male biliary (1.60), ovarian (8.72), and cervical cancer (3.33) with primary gastric cancer. After five years from diagnosis of gastric cancer, secondary cancer occurred in 50 patients (23.4%), and breast cancer, prostate cancer, laryngeal cancer, lung cancer, and hepatocellular carcinoma were the most frequent. CONCLUSION: The O/E ratio showed a significant increase in colorectal, male biliary, ovarian, and cervical cancer with primary gastric cancer, and second primary cancer as the main cause of death for these patients. A follow-up examination for metachronous double primary cancer is needed in order to improve the survival time in patients with gastric cancer.
