Pharmacodynamic Study on Reducing Enzyme and Receding Jaundice of Matrine for Oral Use
- VernacularTitle:口服苦参碱的降酶退黄药效学研究
- Author:
Hui ZHOU
;
Shunmei XIN
;
Zhuqing MA
;
- Publication Type:Journal Article
- Keywords:
Matrine for oral use;
effect on reducing enzyme and receding jaundice;
? naphthy isothiocyanate;
cholestatic jaundice model
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: This article had been ready for creating Matrine capsule by reducing enzyme and receding jaundice of Matrine. Matrine would be not only by intravenously guttae but also by oral use in clinical treatment, so the oral drug could reduce the pain and use more easy for patients. Methods: The experiment used cholestatic jaundice model for ? naphthy isothiocyanate of mice to make high cholerythrin symptom in healthy mice. Results: Pharmacodynamic experiment proved: TBIL and DBIL of high cholerythrin symptom of mice had been reduced, comparing with control groups by Matrine for oral use(75mg/kg and 100mg/kg), and so do SGPT and SGOT. Conclusion: Matrine for oral use had obvious effect on reducing enzyme and receding jaundice.
