Inhibition Effect of Xinnaotong on Endothelial Cells and Platelets Expression Adhesion Molecule in Vitro
- VernacularTitle:心脑通抑制内皮细胞和血小板表达粘附分子
- Author:
Zhongqin LIANG
;
Qun LU
;
Yi ZHU
;
Zhenlun GU
;
Pansheng FAN
;
- Publication Type:Journal Article
- Keywords:
Xinnaotong;
endothelial cell;
pletelet adhesion molecules
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the action of Xinnaotong on adhesion molecule expression by cultured endothelial cells and platelets. Methods: Tumor necrosis factor ?(TNF ?) stimulated ICAM I expression on the cell surface was studied with human umbilical vein endothelial cells(HUVEC).Thrombin stimulated expression of platelet P selectin was studied with human blood platelets. Adhesion molecule expression was measured by flow cytometry. Results: ICAM I molecule expression on HUVEC was significantly stimulated by TNF ?. The stimulatory effect of TNF ? on HUVEC was inhibited by Xinnaotong(0.25～2g/L) in a concentration dependent manner. The same dose of Xinnaotong can inhibit the p selectin expression on human blood platelets stimulated by thrombin. Conclusion: Xinnaotong inhibites expression of adhesion molecues(ICAM I, p selectin) in HUVEC and in human blood platelets.
