Studies on release of pH-dependent gradient-releasing heart-protecting musk pellets in vitro
- VernacularTitle:麝香保心pH依赖型梯度释药微丸的体外释放度研究
- Author:
Hongtao SONG
;
Tao GUO
;
Ruhua ZHANG
;
Yan MA
;
Xian LI
;
Kaishun BI
;
- Publication Type:Journal Article
- Keywords:
pH dependent gradient releasing heart protecting musk pellets (GRHPMP);
borneol;
total ginsenoside;
in vitro release
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To investigate the release of pH dependent gradient releasing heart protecting musk pellets (GRHPMP) in vitro. Methods The pH dependent GRHPMP was prepared by coating with hydroxy propylmethy cellulose, Eudragit ○R L 30D 55 and Eudragit ○R L100/S100, repectively. The release of borneol and total ginsenoside from GRHPMP were determined according to method described in Chinese Pharmacopoeia (2000 ed) at simulated gastrointestinal pH conditions. Results The f 2 value of release data of borneol and total ginsenoside was 79 6. Conclusion The result suggested that, in vitro, the liposoluble borneol and watersoluble total ginsenoside could release simultaneously at a sustained rate.
