Studies on antiarrhythmic portion in Cornus officinalis extract
- VernacularTitle:山茱萸提取液抗心律失常有效部位的研究
- Author:
Lantong ZHANG
;
Leiming REN
;
Jinkun WEN
;
- Publication Type:Journal Article
- Keywords:
extract of Cornus officinalis Sieb. et Zucc.;
antiarrhythmia;
electrophysiology;
action potential;
papillary muscle
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the effective portion in Cornus officinalis Sieb. et Zucc. extract (COE) for the treatment of arrhythmia. Methods Effect of COE on chloroform induced ventricular fibrillation in mice and electrophysiology of isolated guinea pig papillary muscle were studied. Results Antiarrhythmic effect of COE may be related to its prolongation of action potential duration, increase of the absolute value of resting potential and a decrease of autonomy of sinus node. The effective portion in COE may be its total organic acid and a certain yet unknown trace substance, whereas its total glycosides were devoid of such activities. Conclusion Pharmacodynamic and myocardial electrophysiologic studies showed that the total organic acid and a certain unknown trace substance possessed the obvious antiarrhythmic activity.
