Comparison of effects of XIAOYU TABLETS and its constituents on endothelin-1 and nitric oxide in atherosclerotic rabbits
- VernacularTitle:消瘀片及其组分对动脉粥样硬化兔ET-1和NO影响的比较
- Author:
Meilin XIE
;
Zhenlun GU
;
Lujia ZHU
;
Qun LU
;
- Publication Type:Journal Article
- Keywords:
XIAOYU TABLETS;
Radix Salviae Miltiorrhizae;
Frutus Crataegi;
endothelin 1;
nitric oxide
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To determine the rationality of prescription of XIAOYU TABLETS. (Tablet for the elimination of blood stasis). Methods The effects of XIAOYU TABLETS and its individual constituents on endothelin 1 and nitric oxide in atherosclerotic rabbits were observed and compared. Results XIAOYU TABLETS showed stronger actions than its individual constituents (extract of Radix Salviae Miltiorrhizae or Fructus Crataegi) in decreasing the contents of endothelin 1 in plasma and atherosclerotic vessel wall and increasing the contents of nitric oxide in serum and atherosclerotic vessel wall. Conclusion The combine use of Radix Salviae Miltiorrhizae and Fructus Crataegi extracts showed an obvious synergistic effect on reduction of endothelin 1 and elevation of nitric oxide in atherosclerotic rabbits.
