Effect of Notoginsenoside on Cerebral Infarcted Neurotic Dysfunction
- VernacularTitle:三七皂苷对脑梗塞所致神经功能障碍的影响
- Author:
Yiju SHI
;
Guoqing XING
;
Qinghua MENG
;
Jilan PANG
;
- Publication Type:Journal Article
- Keywords:
local cerebral ischemia;
somatosensory evoked potential (SEP);
ultrastructure;
nitric oxide (NO);
notoginsenoside
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of notoginsenoside in various doses on local ischemic neurotic dysfunction and the ultrastructure. Methods: 35 Wistar rats were divided at random. The reversible middle cerebral artery occlusion (MCAO) model was made according to the assessment of the literature. The changes of SEP contents of cerebral cortex NO and SOD, and the changes of the ultrastrcture were recorded by evoked potential electrograph before and after MCAO. Results: notoginsenoside 200mg?kg -1 and 400mg?kg -1 could remarkably alter MCAO, shorten the latent period, improve the dysfuntion induced by MCAO, lower the concentration of NO and enhance the activity of SOD. The differential value in MCAO group was statistically remarkable ( P
