Study of the expression of matrix metalloproteinase and its tissue inhibitor in hepatocellular carcinoma
- VernacularTitle:基质金属蛋白酶及组织抑制剂在肝癌中的表达及与预后的关系
- Author:
Jingsong HU
;
Weirong ZHAI
;
Yue'E ZHANG
;
Jinyu MA
;
Xiaomei ZHOU
;
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Matrix metalloproteinase;
Tissue inhibitor of matrix metalloproteinase
- From:
Chinese Journal of Digestion
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of matrix metalloproteinase (MMP) and the tissue inhibitor of matrix metalloproteinase (TIMP) in hepatocellular carcinoma (HCC) and its relation with the prognosis of patient. Methods MMP 1,MMP 2,MMP 9 and TIMP 2 in human HCC tissue and HCC cell line were measured and quantified with immunohistochemistry, Northern blot hybridization and image analysis. Results MMP 1,MMP 2 and MMP 9 were localized in the cytoplasm of tumor cells. The 5 years survival rate were markedly higher in the cases of MMP 1 negative, MMP 9 negative, both MMP 1 and MMP 2 negative or both MMP 1 and MMP 9 negative staining than that of the positive cases ( P
