Effect of Haimidin on lipid fluidity in erythrocyte membrane and DNA content in normal and H_(22) tumor bearing mice
- VernacularTitle:海嘧啶对H_(22)小鼠完整细胞膜脂流动性及人胃腺癌细胞内DNA含量影响的研究
- Author:
Yubin JI
;
Xiujuan ZHANG
;
Qi KONG
;
Shiyong GAO
;
Baofeng YANG
;
- Publication Type:Journal Article
- Keywords:
Haimidin (HMD);
antitumor mechanism;
membrane lipid fluidity;
DNA of tumor cell
- From:
Chinese Traditional and Herbal Drugs
1994;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the effect of Haimidin(HMD) on erythrocyte membrane of H 22 ascites tumor bearing mice and DNA synthesis in human gastric tumor cell Methods By fluorescence spectrophotometry and laser scanning confocal microscopy Results HMD can lower erythrocyte microviscosity and elevate membrane lipid fluidity of H 22 ascite tumor bearing mice It also reduced DNA fluorescent intensity and DNA content of gastric tumor cells in vitro Conclusion HMD can improve blood circulation of tumor bearing mice, enhance immune adherence of erythrocyte on tumor cells and displays its antitumor activity by interferring DNA synthesis of tumor cells
