Effect of emodin on secretion of TNF_?, IL-1, IL-6, and level of intracellular Ca~(2+) by rat peritoneal macrophage
- VernacularTitle:大黄素对大鼠腹腔巨噬细胞产生的TNF_?、IL-1、IL-6及细胞[Ca~(2+)]_i的影响
- Author:
Jun ZHANG
;
Fuhai WENG
;
Huiqiang LI
;
Zhi YAO
;
- Publication Type:Journal Article
- Keywords:
TNF ?;
IL 1;
IL 6;
[Ca 2+ ] i;
emodin
- From:
Chinese Traditional and Herbal Drugs
1994;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the effect of emodin, the active principle in rhubarb on the secretion of TNF ?, IL 1, IL 6, and [Ca 2+ ] i by rat peritoneal macrophage under different conditions Methods Hypernomic inflammation models of isolated rat peritoneal macrophage were prepared by lipopolysaccharide excitation and the levels of [Ca 2+ ] i and the proinflammatory cytokines TNF ?, IL 1 and IL 6 secreated determined by fluorescence spectrophotometry and bioassay Results Emodin showed a dual regulatory effect on the secretion of proinflammatory cytokines and [Ca 2+ ] i Conclusion It seemed that emodin has a biphasic immuno regulatory effect
