Study on Foeniculum Vulgare Mill as Penetration Enhancer for the Permeation of 5-Fluorouracil
- VernacularTitle:小茴香对5-氟脲嘧啶的促渗作用研究
- Author:
Qi SHEN
;
Lianying XU
;
- Publication Type:Journal Article
- Keywords:
volatile oils of Foeniculum Vulgare Mill;
anethole;
anisaldehyde;
penetration enhancer
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of volatile oils from Foeniculum Vulgare Mill, anisaldehyde, anethole and water extracts on the percutaneous penetration of 5 fluorouracil. Methods: With Valia Chien horizontal diffusion cell and HPLC method to observe the effect of volatile oils of Foeniculum Vulgare Mill, anisaldehyde, anethole on the percutaneous penetration of 5 fluorouracil. Results: The volatile oils of Foeniculum Vulgare Mill, anethole, anisaldehyde possessed the high promoting action on percutaneous absorption of 5 fluorouracil, and their enhancement ratio are 7.14, 4.17, 9.54, respectively. Conclusion: The volatile oils of Foeniculum Vulgare Mill, anethole, anisaldehyde enhance the skin permeation of 5 fluorouracil effectively.
