APOPTOSIS IN THE DEVELOPMENT OF KIDNEY IN MOUSE
- VernacularTitle:小鼠肾脏发育中的细胞凋亡
- Author:
Min GUO
;
Jing DU
;
Changzheng MU
;
Youzhi SHAO
;
- Publication Type:Journal Article
- Keywords:
Kidney development;
Apoptosis;
TUNEL method;
TEM;
Mouse
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe apoptosis of renal development in mouse. Methods Light,electron microscopy and TUNEL method were used. Results The apoptosis could be easily found in cells between S like body in nephrogenic zone and in renal corpuscles before birth, especially at 14 18 days prenatally. The apoptotic cells in epithelia of renal tubule or collecting duct could be observed in postnatal renal medulla. In medullary papilla the cell death peaked around postnatal day 7. Electron microscopy revealed that apoptotic cells were ingested by neighboring cells. Some apoptotic cells detached from epithelia into the lumen of tubule or duct. Conclusion This study provides morphologically some evidences of apoptosis in the mouse kidney embryonically and postnatally. The apoptosis in cortex was apparently related to the development of nephrogenic zone and renal corpuscles; and the apoptosis in medulla might play an important role in the development of renal tubular epithelia. [
