Study on Nasal Mucosa Absorption in Vivo of Tetramethylpyrazine Hydrochloride in Rats
- VernacularTitle:盐酸川芎嗪对大鼠在体鼻粘膜吸收研究
- Author:
Zhinan GONG
;
Lianying XU
;
Jingzhong SONG
;
Shuren MA
;
Jiansheng TAO
;
- Publication Type:Journal Article
- Keywords:
tetramethylphyrazine hydrochloride (TMP HCl);
nasal circulatory perfusion test;
nasal mucosa absorption;
absorption rate constants
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the characteristic of nasal mucosa absorption in vivo of tetramethylpyrazine hydrochloride (TMP HCl) in rats. Methods: The nasal circulatory perfusion test of TMP HCl was performed in rats.Results: The absorption rate constants was increased with the increasing of the concentration of TMP HCl; The absorption rate constants was increased with the elevating of pH values at the pH value range of 4.70～7.00. Conclusion:When the pH value of nasal circulatory perfusion liquid of TMP HCl is 7.00, the nasal mucosa absorption is optimal.
