Determination of in vitro Percutaneous Rate and in vitro of Release of Compound Patch of Hyperosteogeny
- VernacularTitle:复方骨质增生贴剂体外透皮速率测定和体外释放研究
- Author:
Yingai XU
;
Yanru GE
;
Yajun WANG
;
Ying JIN
;
Fenglong LI
;
- Publication Type:Journal Article
- Keywords:
hyperosteogeny;
percutaneous absorption;
ferulic acid;
HPLC
- From:
Chinese Traditional Patent Medicine
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the feasibility of percutaneous absorption of Compound Patch of Hyperosteogeny(CPH). Methods: The content of ferulic acid,an index composition in percutaneous receptor fluid and release receptor fluid were determined by HPLC.Results: The results of in vitro transdermal delivery experiment and in vitro release experiment showed that ferulic acid permeated at the constant speed of 0.2142?g?cm -2 ?h -1 in 24 hours and its release coincided with Higuchi Equation.Futhermore,the release rate was 14.53?g?cm -2 ?h -1/2 . Conclusion: CPH is a skeleton controlledtransdermal delivery system whose permeation speed is limited by skin.
