Preparation of Rhizoma Corydalis Analgesic Lapsules with Pellet Technology and Comparison of Dissolution Rates of Capsules and Tablets
- VernacularTitle:用微丸技术制备元胡止痛胶囊与元胡止痛片溶出度的比较
- Author:
Lanqian HE
;
Qi PAN
;
Peihua LIU
;
- Publication Type:Journal Article
- Keywords:
pellets;
capsule;
sugarcoating tablet;
disintegration rate;
dissolution rate
- From:
Chinese Traditional Patent Medicine
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the reasonableness of the preparation procedure of Rhizoma Corydalis Analgesic Pellets and the dosage form change from tablets into capsules. Methods: The preparation procedure of 3 batches of Rhizoma corydalis Analgesic Pellets was studied by TLC analyzing and determining of their disintegration time and dissolution rate in vitro,and comparing of the results between pellets and tablets.Results: The qualitative identification spots of capsales and tablets were the same. The disintegration time was 5 min for capsules or 3 min for tablets. The dissolution rates of 3 batches were all quick. There were no significant differences in the dissolution parameters T 50 、 T d and m among them ( P
