The Effect of Tiaozhixin NO/ET、6-PGF_2/TXB_2 Hemorrhedoge of Rats with Hyperlipoidemia
- VernacularTitle:调脂新对高脂血症大鼠一氧化氮/内皮素、6-keto-PGF_(1a)/TXB_2及血液流变学的影响
- Author:
Xiaomei ZI
;
Qingyun LIU
;
Zhongmin YU
;
Zhaobin WU
;
Fuqing ZHANG
;
- Publication Type:Journal Article
- Keywords:
Tiaozixian(TZX);
nitric oxide;
endotheliotoxin;
Endothelim (ET);
prostacyclin (PGI 2);
thromboxane B 2(TXB 2);
hemorrheology
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the influences of Tiaozhixin(TZX) on NO/ET, 6 keto PGF 1a /TXB 2 and hemorrheology rats with hyperlipoidemia. Methods: The rat hyperlipoidemia and early atheroscleorsis models were established by feeding high lipid diet for 40 days. Meanwhile TZX was taken by oral administration at the dosages of 40、80g/kg. The levels of NO、ET 1、6 keto PGF 1a and TXB 2 in serum were determind, and the hemorrheology markers were observed. Results: TZX could raise the levels of NO in serumobviourly ET 1 level of the normal and model rats. The large dose of TZX could increase 6 keto PGF 1a content remarkably which benefits maintenance of the balances of 6 keto PGF 1a /TXB 2. It could lower the whole blood specific viscosity, whole blood reduction specific viscosity, plasma specific viscosity; aggregation index of RBC; shorten RBC electrophoresis time; also decrease fibrinogen content; inhibit the platelet aggregation of normal rats induced by ADP. Conclusion: TZX can improve the abnormal hemorrheology and recover the balance of TXB 2/6 keto PGF 1a and NO/ET of rats with hyperlipoidemia, which might be one of mechanisms of antiatherosclerosis action.
