Effect of sophoramine on T lymphocytes in rats of skin allografting
- VernacularTitle:槐胺碱对皮肤移植大鼠T淋巴细胞的影响
- Author:
Pei ZHANG
;
Lili JI
;
Chenguang WANG
;
Shuhua LI
;
- Publication Type:Journal Article
- Keywords:
sophoramine(SA);
skin allografting;
T lymphocyte
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Object In order to obtain further evidence of therapeutic efficacy of sophoramine (SA) *, its effect on transplantation rejection was studied with simultaneous exploration of its mechanism of action Methods Number of T lymphocyte and its sub sets of skin allografted rat model were determined by immunofluorescence technique, and proliferation of T lymphocyte was assessed by thiazolyl blue (MTT) assay Results SA reduced the CD 3 and C 4 cell counts, lowered CD 4/C 8 ratio, inhibited T lymphocyte proliferation and prolonged the survival time of skin allografted rat Conclusion SA could inhibit transplantation rejection by inhibiting the function of T lymphocyte with simultaneous reduction of lymphocyte count
