Studies on effect of main active principles in ZHIGANCAO DECOCTION on  myocardial electrophysiology

VernacularTitle:炙甘草汤主要有效成分对心肌生理特性的影响
Author: Lanying CHEN ; Qi CHEN ; Ronghua LIU ; Ming BI ; Lijuan ZHOU ; Wenhong LI ;
Publication Type:Journal Article
Keywords: ZHIGANCAO DECOCTION; glycyrrhizic acid (GA); ginseng total saponin (GTS); Ophiopogon total saponin (OTS); myocardial electrophysiological characteristics
From: Chinese Traditional and Herbal Drugs 1994;0(02):-
CountryChina
Language:Chinese
Abstract: Object To study the influence of main active principles of ZHIGANCAO DECOCTIDN (ZD), glycyrrhizic acid (GA), ginseng total saponin (GTS) and Ophiopogon total saponin (OTS) on electrophysiology of isolated rat myocardium Methods The influence of GA, GTS and OTS on the automaticity, excitability and functional refractory period of isolated rat atrium and papillary muscle were studied in comparison with ZD made free of the above said active ingredients Results The combine use of GA, GTS and OTS significantly decreased the automaticity, inhibited excitaibility and prolonged the functional refractory period of isolated rat atrium; decreased the automaticity and arrhythmia of papillary muscle induced by epinephrine, while ZD made free of GS, GTS and OTS showed much less effect than the intact decoction Conclusion GA, GTS and OTS proved to be the main effective ingredients responsible for the antiarrhythmic activity of ZD