Study on Preparation and Stability of the Solid Dispersion of Radix Arnebiae seu Lithospermi
- VernacularTitle:紫草浸膏固体分散物的制备及稳定性的研究
- Author:
Xiujuan PANG
;
Xiaohong LIU
;
Fude CUI
;
Changshan SUN
;
- Publication Type:Journal Article
- Keywords:
Radix Arnebiae seu Lithospermi;
solid dispersion;
dissolution rate;
stability
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To enhance the dissolution rate in vitro and bioavailability in vivo of the active components of extraction of Radix Arnebiae seu Lithospermi. Methods: Solid dispersion of extract of Radix Arnebiae seu Lithospermi were prepared with solid dispersion technology, X ray diffraction and stability experiments were also carried out. Results: The dissolution rates in vitro of the active components of extraction of Radix Arnebiae seu Lithospermi solid dispersion were obviously raised and stable, and the solid dispersion was not easy to age. Conclusion: The dissolution rate in vitro of the active components in Radix Arnebiae seu Lithospermi can be inproved greatly by the solid dispersion using PVP and HPMC as a carrier.
