Study on the effect of suicidal gene of cytosine deaminase on colorectal carcioma
- VernacularTitle:原位转导胞嘧啶脱氨酶自杀基因对大肠肿瘤的杀伤作用
- Author:
Long CUI
;
Yanzhen LING
;
Zhenggang ZHU
;
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasm;
Gene therapy;
In situ
- From:
Chinese Journal of Digestion
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cytosine deaminase(CD)/ 5-FC system in inhibiting growth of LoVo colorectal carcinoma grated in nude mice.Method The retroviral vector pCD2 containing CD suicidal gene was packaged in PA317 cells,the supernatant of recombinant retrovirus was then injected into tumor sites.Result Obvious regression of the tumor occurred after serial intraperitoneal administration of the prodrug for the 5-FC.Conclusion CD gene can be a useful tatic in the comprehensive treatment of colorectal carcinomas.
