Typical multidrug resistance in chemotherapy of thirty cases with colorectal cancer
- VernacularTitle:典型多药耐药在30例大肠癌标本化疗药敏实验中的作用
- Author:
Lijuan FENG
;
Xichun ZHANG
;
Zhongen PENG
;
- Publication Type:Journal Article
- Keywords:
Drug resistance,multiple;
Colorectal neoplasm;
Microbial sensitivity test
- From:
Chinese Journal of Digestion
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the typical multidrug resistance in colorectal cancer chemotherapy with drugs including 5-Fu,MMC and cisplatin. Methods The expression of mdrl gene and GP170 in thirty colorectal cancer specimens were detected by reverse transcription polymerase chain reaction and immunohistochemistry.At the same time,the sensitivity of the cancer cells to six common chemotheraputic drugs were also detected by MTT colorimetric assay. Results In thirty colorectal cancer specimens,the expression of mdr_1 gene(63.3%) and GP170 (73.3%) were not different,and was concordant with the results of ADM cytotoxicity assay (P
