Effects of Ligustrazine on the Thrombosis of PTRA Site in Canine Renal Artery Stenosis Model
- VernacularTitle:川芎嗪对犬血管成形术局部血栓形成的影响
- Author:
Junsheng LIANG
;
Nengshu HE
;
Shengyong WU
;
- Publication Type:Journal Article
- Keywords:
Angioplasty,Transluminal;
Ligustrazine;
Thrombus
- From:
Journal of Interventional Radiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To understand the effect of ligustrazine on preventing the thrombosis "after percutaneous transluminal angioplasty(PTA).Materials and Methods:Dogs models(n=10)with exper- imental renal arterial stenosis were selected and randomly divided into control and experimental groups with 5 dogs for each. Experimental group dogs were injected ligustrazine(40mg/kg)15 days before PTRA.Peripheral blood samples were collected before recelived drug,before and 4 hours after PTRA in the experiment group;before and 4 hours after PTRA in the control group.Plasma concentrations of thromboxane B2_(TXB_2)and 6-keto-PGIl? were determined by radioimmunoassay.Rates of platelet ag- gregation were also determined by ADP-induced.All dogs were killed 4 hours after PTRA.Renal arteries were removed before killing.The thrombus volume at PTRA sites were measured.Results:Liguslrazine might significantly inhibit platelet aggregation,decrease TXA_2 produced by platelet and increase PGI_2 synthesized in the blood vessel.Therefore,ligustrazine might significantly inhibit thrombosis at the PTRA sites.It Suggests that Ligustrazine could be an effective drug for preventing restenosis of thromboses after PTA.
