The observation on the theropeutic effect injected into rat's heptome with ricin and the research in the inhibit of marrow
- VernacularTitle:蓖麻蛋白对裸鼠肝癌瘤体内注射的疗效及骨髓抑制的研究
- Author:
Chengyou GONG
;
Shuguang CHU
;
Lingji CHEN
;
- Publication Type:Journal Article
- Keywords:
Animals experiments;
Hepotic;
Ricin emulsion
- From:
Journal of Interventional Radiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Parpose:To observe the therapeutic effects of the ricin's intervention in treating the hepatic carcinoma and to compare the restraint effect to bone manrrow caused by ricin and mitomicin C.Materials and Methods:Use human grafted hepatic carcinoma to naked rat as transplanted rat's liver cancer model.The therapeutic effects of ricin(4?g/kg)were compared with that of lipiodel-emusified riein(8?g/kg)and mitomicin C(500ug/kg)(all the dosages were of the one third of the LD50),with saline injected liver cancers as the control.To observe the tumour's growth inhibition rate,-FP hemogram and marrow change.Results:The growth of turners in group of ricin,lipiodel-emulified ricin,mitomicin C was inhibited,result in tumour necrosis.The inhibition in marrow showed more obvious in mitomicin C than in ricin.The- FP's reduction was significant in comparision with that of the control group,however,there were no remarkable difference among the three drug forms.Conclusion:Ricin has remarkable therapeutic effect on hepatic carcinoma.Ricin's emulsion was stable providing experimentd basis for the toxicity to marrow is clearly lower than mitomicim C
