A Subacute Toxicological Study on Radix Rhododentri Mollis
- VernacularTitle:闹羊花根对狗肝、肾亚急性毒性的研究
- Author:
Zuofei WANG
;
Shixing LIU
;
Fanbo ZENG
;
- Publication Type:Journal Article
- Keywords:
RADIX RHODODENTRI MOLLS/pharmacology RADIX RHODOENTRI MOLLS/toxicity LIVER/pathology KIDNEY/pathology ANIMAL DOGS
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Sixteen dogs were allocated to 4 groups in equal number and were fed with Rad ix Rhod od end ri Mollis 0.170, 0.345 and 1.420 g/kg for three months respectively, with one group as control. The results showed that Rad ix Rhod od end ri Mollis can cause focal necrosis, edema, ballooning degeneration and fatty degeneration of liver cells. It can also increase the permeability of glomerulus, and cause edema and even ballooning degeneration of renal tubular epithelial cells. Biochemical analysis showed that GPT and BUN apparently increased. Urine analysis showed that qualitative examination of protein, epithelial cells, white and red blood cells were all positive. It is considered that long-term administration of Rad ix Rhod od end ri Mollis can cause functional and structural damage of liver and kidney, and timely suspension of the drug and treatment may render the damage.
