AN OBSERVATION ON PHARMACODYNAMICS AND TOXICITY OF SHIWEI DANGGUIYIN
- VernacularTitle:十味当归饮药效学及毒性观察
- Author:
Bojun YUAN
;
Guocai LU
;
Shuying ZHANG
;
Junping LIU
;
Changhong GU
;
Zhurui DAI
;
Yuqiang FANG
;
Fengehuan GUO
;
Chun ZHANG
;
- Publication Type:Journal Article
- Keywords:
@SHIWEI DANGGUIYIN/pharmacology;
@SHIWEI DANGGUIYIN/toxicity;
ANALGESIC
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Shiwei Dangguiyin(SWDGY)is mainly composed of Radix Angelicae Sinensis,Radix Adenophorae,Radix Notogenseng,Radix Bupleuri,etc. Oral administration of SWDGY could significantly inhibit the metatarsal swell- ing eaused by dimethylbenzene in rats,raise the pain threshold in hot-plate test and depress the torsive reaction caused by acetic acid in mice.In vitro SWDGY exerted bacteriostatic and bacteriocidal effects on Staphylococcus aureus,Bacil- lus pyocyaneus,Escherichia coli,Streptococcus A,B and C.It was shown that SWDGY possessed anti-inflammatory,analgesic and antiseptic effects in vitro.In mice LD_(50) of SWDGY by oral administration was more than 840g/kg.Affer cral adminstration in a daily dose of 189.Sg/kg continuously for one month in rats, no toxic reactions appeared,This dosage was 118.6 times as much as the clinical one.
